December 1, 2023
Get to know the importance of Folic acid. Learn how to differentiate folic acid from folate, determine individual needs, manage folic acid deficiency, and stay healthy.


Many people have heard of folic acid, but few are familiar with its benefits or the reasons why it’s so important. In some cases, confusion even arises about what folic acid is and how it differs from folate. This article will provide a comprehensive guide to folic acid, including its definition, benefits, dietary sources, and effects on pregnancy. By the end of the article, readers will have a thorough understanding of this essential nutrient.

What is Folic Acid and Why is it Important?

Folic acid is a synthetic form of vitamin B9, a water-soluble vitamin that plays a crucial role in bodily functions. As a synthetic form, it is more stable and easier to absorb than its naturally occurring counterpart, folate. Folate can be found in some foods, while folic acid is commonly used in supplements and fortified foods. Folic acid is necessary for a variety of reasons. It helps the body produce and maintain new cells, and it is involved in DNA synthesis and repair. Proper intake of folic acid can reduce the risk of certain birth defects, such as neural tube defects, and is essential for optimal brain function.

The Benefits of Folic Acid

Research has shown that folic acid not only prevents birth defects but also offers many other health benefits, from improving mood to reducing the risk of certain cancers.

Mood-boosting effects

Folic acid plays a critical role in brain function and mood regulation. It has been linked to a decrease in the risk of depression and may help reduce symptoms in those who already suffer from depression. A deficiency in folic acid can lead to irritability, confusion, and even impaired memory and concentration. By increasing folic acid levels, individuals may experience an overall improvement in mood and cognitive function.

Improvement in heart and brain health

Folic acid has also been linked to improved heart health by controlling homocysteine levels, an amino acid that can damage arteries and increase the risk of heart disease. Additionally, folic acid may help boost cognitive function, improve memory, and reduce the risk of age-related mental decline.

Reduced risk of certain cancers

There are many forms of cancer, and some research suggests that folic acid may reduce the risk of some types. For example, colon and cervical cancers have been linked to low folic acid levels, and studies have shown that increased intake may reduce the risk of these cancers. While the research is not conclusive, it’s still worth considering folic acid as a preventative measure.

Folic Acid vs. Folate: What’s the Difference?

Folate and folic acid are often used interchangeably, but they are not quite the same thing. Folate refers to the naturally occurring form of vitamin B9 that is found in foods like spinach, asparagus, and lentils. Folic acid, on the other hand, is the synthetic form of vitamin B9 that is used in fortified foods and supplements.

Difference in chemical structure

The most significant difference between folate and folic acid is their chemical structure. Folate is a naturally occurring nutrient, which means the body can metabolize it more efficiently. Folic acid, being a synthetic form, may not be readily absorbed, especially for individuals with digestive issues. This may lead to lower absorption levels and cause some individuals to have lower than ideal folic acid levels.

Difference in dietary sources and absorption

While folate is naturally available in many foods, the amount of folic acid in fortified foods and supplements can be more easily regulated and controlled. This means it is easier to ensure adequate intake levels when consuming folic acid in fortified foods and supplements. Additionally, absorption of these synthetic sources is typically not affected by other nutrients commonly found in food.

Top Sources of Folic Acid

While folic acid supplementation is great, getting it through dietary sources is even better. A diet rich in whole foods is typically enough to meet an individual’s daily requirement of folic acid.

Importance of getting folic acid through diet

Whole foods contain an abundance of nutrients, including folic acid, that the body can more readily absorb. They also offer other compounds that support overall health, such as fiber and antioxidants. Consuming foods rich in folic acid also reduces the risk of consuming synthetic supplements which can sometimes lead to an imbalance with other vitamins and minerals in the meal. It’s important to consider that over-dependence on synthetic supplements can sometimes lead to over-consumption which may cause toxic symptoms.

Dietary sources of folic acid

Common folic acid food sources include leafy green vegetables, such as spinach and collard greens, as well as beans and lentils. Additionally, many grains, such as enriched pasta and bread, are fortified with folic acid. Meat and dairy products also contain small amounts of folic acid.

Explanation of how to determine individual needs for folic acid

The daily recommended amount of folic acid varies based on age, sex, and other factors. For most adults, the recommended intake is 400 mcg per day. Pregnant women have specific needs as well, hence why it’s important to consult with a healthcare professional for the recommended dosage to their specific case.

The Role of Folic Acid in Pregnancy

Folic acid is an essential nutrient for pregnant women, which is why pre-natal vitamins are recommended. Here’s why:

Explanation of why folic acid is important during pregnancy

Folic acid plays an important role in the formation of the neural tube before birth, which eventually develops into the baby’s brain and spinal cord. When a woman is pregnant and doesn’t get enough folic acid, her baby is at risk of developing neural tube defects. Unfortunately, many women have low levels of folic acid during early pregnancy and hence healthcare professionals recommend supplementation.

The recommended intake for pregnant women

The CDC recommends that all women of childbearing age consume 400-800 mcg of folic acid daily, regardless of pregnancy status. For pregnant women, supplementation of 600-800 mcg daily is suggested. This assists the adequate development of the baby without putting the mother or the baby at risk of toxicity.

The benefits of supplementing and how to choose the right supplement

Dietary intake is good, but when an expecting mother needs an extra boost, supplementation may be necessary. Certain supplements offer the right amount of folic acid without requiring over-consumption of other vitamins. Expectant mothers should look for prenatal vitamins that contain at least 400-800 mcg of folic acid, preferably with other recommended vitamins and minerals. Always consult with a healthcare professional before supplementing, especially if taking other medication to avoid toxicity and overdose.

Folic Acid Deficiency

Explanation of what happens when the body is deficient in folic acid

A deficiency in folic acid can result in anemia, irritability, weakness, and even impaired cognitive function. It can also lead to megaloblastic anemia, which is a type of anemia characterized by red blood cells that are larger than normal.

The risks and causes of deficiency

Those who are at higher risk of folic acid deficiency include pregnant women, individuals with certain digestive issues, and those who use alcohol excessively. Additionally, some medications, such as certain seizure medications, can interfere with folic acid absorption.

Importance of addressing a deficiency

It is important to address folic acid deficiencies as soon as possible, as they can lead to serious complications. For more severe cases of deficiency, healthcare professionals may suggest supplementation or offer advice on increasing dietary intake. It’s recommended to consult with a healthcare provider if you suspect you have a deficiency in folic acid.


Folic acid is an essential nutrient that plays a significant role in overall health, mood regulation, and preventing birth defects. It is crucial to ensure adequate intake to help reduce the risk of deficiency and reap the benefits it provides. Meeting daily requirements can be accomplished through a healthy diet rich in whole foods, as well as through supplementation in some cases. For pregnant women, folic acid is particularly important to ensure the proper development of the growing fetus. By ensuring adequate intake, individuals can enjoy the many benefits of this essential nutrient.

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