April 13, 2024
Learn more about the connection between Metformin and drowsiness. This article discusses the causes of drowsiness and provides tips for managing Metformin-induced fatigue.


If you are taking Metformin to regulate your glucose levels, you may be experiencing drowsiness and fatigue. This is a common side effect that affects a significant number of people. Understanding why this happens and how to deal with it is crucial for maintaining your quality of life.

In this article, we will discuss the connection between Metformin and sleepiness. We will also provide tips for managing Metformin-induced fatigue so that you can get the most out of your medication.

The Truth About Metformin and Drowsiness: What You Need to Know

Most people take Metformin to regulate glucose levels in the blood. This medication works by lowering the body’s glucose production and increasing its sensitivity to insulin. Although Metformin is an effective medication, it comes with several side effects, including drowsiness and fatigue.

Studies have shown that approximately 1 in 10 people experience drowsiness when taking Metformin. However, fatigue’s prevalence could be higher because people might not report it as a symptom.

Several factors contribute to drowsiness when taking Metformin, such as:

  • Low blood sugar levels
  • Dehydration
  • Anemia (low red blood cell count)
  • Metabolic acidosis

The Connection Between Metformin and Sleepiness: Explained

Metformin’s primary mechanism of action is to regulate glucose production in the liver and improve insulin sensitivity. However, the medication’s interactions with other hormones in the body could explain why some people experience drowsiness.

Metformin increases dopamine levels in the brain, which can trigger drowsiness. Some studies suggest that Metformin also decreases serotonin levels, which could result in changes to your sleep-wake cycle and circadian rhythm. These changes could make it harder to fall asleep at night and increase daytime sleepiness.

Individuals metabolize Metformin differently, which could also explain why some people feel drowsier than others.

Feeling Tired on Metformin? Here’s What You Can Do

Managing Metformin-induced fatigue involves two approaches; lifestyle changes and medication recommendations. Below are some tips for managing Metformin-induced fatigue:

  • Stay hydrated by drinking plenty of water.
  • Eat a balanced diet rich in nutrients to support metabolic function.
  • Avoid skipping meals as this could cause your blood glucose level to drop.
  • Get enough sleep and try sticking to a regular sleep schedule.
  • Avoid taking Metformin before bedtime as this could interfere with sleep quality.

If you continue to experience drowsiness while taking Metformin despite following the above tips, it’s essential to contact your doctor to adjust your dosage or consider alternative medications. Any change to your medication regimen should be made under the guidance of a healthcare professional.

Why Some People Experience Daytime Sleepiness on Metformin (And Others Don’t)

Several theories explain why some individuals experience more severe symptoms than others when taking Metformin.

  • Weight: Being overweight or obese can contribute to drowsiness as it enhances insulin resistance, making it harder for Metformin to regulate glucose levels effectively.
  • Dosage: Taking the highest recommended dosage could make you sleepier.
  • Length of use: People who have been taking Metformin for an extended period might build up a tolerance, reducing its effectiveness.

Can Metformin Actually Help You Sleep Better at Night?

Recent research has shown that taking Metformin could help improve sleep quality, especially in individuals with type 2 diabetes. Managing glucose levels is crucial for maintaining a healthy sleep cycle. Fluctuations in glucose levels could interfere with sleep quality and, as a result, contribute to daytime sleepiness.

Metformin’s ability to regulate glucose levels could help improve sleep quality and prevent daytime drowsiness. However, it’s crucial to note that Metformin does not work for everyone, and the effectiveness of the medication varies from individual to individual.

Managing Metformin Side Effects: Dealing with Fatigue and Drowsiness

Managing Metformin-induced drowsiness involves several strategies:

  • Monitor your blood sugar levels regularly to avoid hypoglycemia (low blood sugar levels).
  • Maintain a healthy and balanced diet rich in vitamins, minerals, and nutrients.
  • Avoid consuming alcohol while taking Metformin as this could increase drowsiness.
  • Ensure you are getting enough restful sleep each night.
  • Speak to your doctor to adjust your dosage, especially if you continue to experience severe fatigue despite implementing lifestyle changes.

All You Need to Know About Metformin and Sleep Disturbances

In addition to drowsiness, Metformin could also lead to sleep disturbances such as nighttime waking, which could interfere with your sleep quality. Below are some tips for dealing with sleep disturbances caused by Metformin use:

  • Avoid eating large meals before bedtime as this could interfere with sleep quality and reduce glucose levels before you sleep.
  • Avoid taking Metformin before bedtime. Instead, take it during the day.
  • Try relaxation techniques such as meditation and deep breathing exercises to manage stress and anxiety levels.


Metformin is a common medication used to regulate glucose levels in the blood. While the medication is safe and effective, it comes with several side effects, including drowsiness and fatigue. Managing this side effect involves implementing lifestyle changes and medication recommendations. If the side effects persist, it’s essential to speak to a healthcare professional before making any significant changes to your medication regimen.

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